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September 15, 2025

017 Exercise Selection - How to pick the exercises needed to maximally develop a muscle

In this episode of Hypertrophy: Past and Present, Jake and Chris discuss Sig Klein’s extensive routine and use it as a springboard to tackle one of the biggest programming questions: how much exercise variety do you really need for maximal growth?

Key topics include:

  • How neuromechanical matching explains which motor units get recruited first

  • Voluntary activation deficits - why bigger muscles and bigger lifts mean some motor units aren't recruited

  • How to use unilateral work to meaningfully increase recruitment

  • Why some muscles require greater exercise variation than others