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October 19, 2025

022 How intra-workout carbohydrates reduce supraspinal CNS fatigue

In this episode of Hypertrophy: Past and Present, Jake and Chris unpack Steve Reeves’ 1947 pre-competition full-body routine, then dive into why the Silver-Era were such advocates of orange juice + honey during training. We assess the building research on carbohydrate mouth-rinsing, what this tells us about supraspinal CNS fatigue, and how the performance increase from carbohydrate mouth-rinsing differs from the performance increase from creatine supplementation. 

Key topics include:

  • Steve Reeves’ 1947 pre-comp full-body plan

  • What carbohydrate mouth-rinsing is doing and intra-workout carbohydrates

  • Why everyone experiences supraspinal CNS fatigue during strength training and what you can do about it

  • Why creatine adds reps without adding stimulus, but carbs can add stimulating reps